diff --git a/.zuul.yaml b/.zuul.yaml
index 5a58d743fe..3278eeb9e0 100644
--- a/.zuul.yaml
+++ b/.zuul.yaml
@@ -90,7 +90,7 @@
     name: devstack-single-node-fedora-latest
     nodes:
       - name: controller
-        label: fedora-34
+        label: fedora-35
     groups:
       - name: tempest
         nodes:
@@ -729,6 +729,10 @@
     voting: false
     vars:
       configure_swap_size: 4096
+      # Python 3.10 dependency issues; see
+      # https://bugs.launchpad.net/horizon/+bug/1960204
+      devstack_services:
+        horizon: false
 
 - job:
     name: devstack-platform-fedora-latest-virt-preview
diff --git a/files/rpms/swift b/files/rpms/swift
index faf0a3175a..a838d7839e 100644
--- a/files/rpms/swift
+++ b/files/rpms/swift
@@ -4,4 +4,4 @@ memcached
 rsync-daemon
 sqlite
 xfsprogs
-xinetd # not:f34,rhel9
+xinetd # not:f35,rhel9
diff --git a/lib/apache b/lib/apache
index cbe61adf34..f29c7ea2cb 100644
--- a/lib/apache
+++ b/lib/apache
@@ -85,7 +85,12 @@ function install_apache_uwsgi {
     if is_ubuntu; then
         local pkg_list="uwsgi uwsgi-plugin-python3 libapache2-mod-proxy-uwsgi"
         install_package ${pkg_list}
-    elif is_fedora && ! is_openeuler; then
+    # NOTE(ianw) 2022-02-03 : Fedora 35 needs to skip this and fall
+    # into the install-from-source because the upstream packages
+    # didn't fix Python 3.10 compatibility before release.  Should be
+    # fixed in uwsgi 4.9.0; can remove this when packages available
+    # or we drop this release
+    elif is_fedora && ! is_openeuler && ! [[ $DISTRO =~ f35 ]]; then
         # Note httpd comes with mod_proxy_uwsgi and it is loaded by
         # default; the mod_proxy_uwsgi package actually conflicts now.
         # See:
diff --git a/stack.sh b/stack.sh
index c92cc79b40..0082b99f11 100755
--- a/stack.sh
+++ b/stack.sh
@@ -227,7 +227,7 @@ write_devstack_version
 
 # Warn users who aren't on an explicitly supported distro, but allow them to
 # override check and attempt installation with ``FORCE=yes ./stack``
-SUPPORTED_DISTROS="bullseye|focal|f34|opensuse-15.2|opensuse-tumbleweed|rhel8|rhel9|openEuler-20.03"
+SUPPORTED_DISTROS="bullseye|focal|f35|opensuse-15.2|opensuse-tumbleweed|rhel8|rhel9|openEuler-20.03"
 
 if [[ ! ${DISTRO} =~ $SUPPORTED_DISTROS ]]; then
     echo "WARNING: this script has not been tested on $DISTRO"