diff --git a/ovsdbapp/api.py b/ovsdbapp/api.py
index ffe0cf1f..1c43cb34 100644
--- a/ovsdbapp/api.py
+++ b/ovsdbapp/api.py
@@ -14,17 +14,10 @@
 
 import abc
 import contextlib
-
-import six
-try:
-    # Python 3 no longer has thread module
-    import thread  # noqa
-except ImportError:
-    import threading as thread
+import threading
 
 
-@six.add_metaclass(abc.ABCMeta)
-class Command(object):
+class Command(object, metaclass=abc.ABCMeta):
     """An OVSDB command that can be executed in a transaction
 
     :attr result: The result of executing the command in a transaction
@@ -41,8 +34,7 @@ class Command(object):
         """
 
 
-@six.add_metaclass(abc.ABCMeta)
-class Transaction(object):
+class Transaction(object, metaclass=abc.ABCMeta):
     @abc.abstractmethod
     def commit(self):
         """Commit the transaction to OVSDB"""
@@ -69,8 +61,7 @@ class Transaction(object):
             self.result = self.commit()
 
 
-@six.add_metaclass(abc.ABCMeta)
-class API(object):
+class API(object, metaclass=abc.ABCMeta):
     def __init__(self, nested_transactions=True):
         # Mapping between a (green)thread and its transaction.
         self._nested_txns = nested_transactions
@@ -105,7 +96,7 @@ class API(object):
         # ojbect() is unique, so if we are not nested, this will always result
         # in a KeyError on lookup and so a unique Transaction
         nested = nested and self._nested_txns
-        cur_thread_id = thread.get_ident() if nested else object()
+        cur_thread_id = threading.get_ident() if nested else object()
 
         if cur_thread_id in self._nested_txns_map:
             yield self._nested_txns_map[cur_thread_id]
diff --git a/ovsdbapp/backend/ovs_idl/command.py b/ovsdbapp/backend/ovs_idl/command.py
index 12988b2c..6b9a940c 100644
--- a/ovsdbapp/backend/ovs_idl/command.py
+++ b/ovsdbapp/backend/ovs_idl/command.py
@@ -15,8 +15,6 @@
 import collections
 import logging
 
-import six
-
 from ovsdbapp import api
 from ovsdbapp.backend.ovs_idl import idlutils
 from ovsdbapp.backend.ovs_idl import rowview
@@ -162,7 +160,7 @@ class DbAddCommand(BaseCommand):
                 # Since this operation depends on the previous value, verify()
                 # must be called.
                 field = getattr(record, self.column, {})
-                for k, v in six.iteritems(value):
+                for k, v in value.items():
                     if k in field:
                         continue
                     field[k] = v
diff --git a/ovsdbapp/backend/ovs_idl/connection.py b/ovsdbapp/backend/ovs_idl/connection.py
index 347f95c9..3cc676fb 100644
--- a/ovsdbapp/backend/ovs_idl/connection.py
+++ b/ovsdbapp/backend/ovs_idl/connection.py
@@ -14,12 +14,12 @@
 
 import logging
 import os
+import queue
 import threading
 import traceback
 
 from ovs.db import idl
 from ovs import poller
-from six.moves import queue as Queue
 
 from ovsdbapp.backend.ovs_idl import idlutils
 from ovsdbapp import exceptions
@@ -32,7 +32,7 @@ else:
 LOG = logging.getLogger(__name__)
 
 
-class TransactionQueue(Queue.Queue, object):
+class TransactionQueue(queue.Queue, object):
     def __init__(self, *args, **kwargs):
         super(TransactionQueue, self).__init__(*args, **kwargs)
         self._wait_queue = connection_utils.WaitQueue(
@@ -41,7 +41,7 @@ class TransactionQueue(Queue.Queue, object):
     def get_nowait(self, *args, **kwargs):
         try:
             result = super(TransactionQueue, self).get_nowait(*args, **kwargs)
-        except Queue.Empty:
+        except queue.Empty:
             return None
         self._wait_queue.alert_notification_consume()
         return result
@@ -142,7 +142,7 @@ class Connection(object):
         # run when we are started
         try:
             self.txns.put(txn, timeout=self.timeout)
-        except Queue.Full:
+        except queue.Full:
             raise exceptions.TimeoutException(commands=txn.commands,
                                               timeout=self.timeout)
 
diff --git a/ovsdbapp/backend/ovs_idl/idlutils.py b/ovsdbapp/backend/ovs_idl/idlutils.py
index 505fa798..ab924b10 100644
--- a/ovsdbapp/backend/ovs_idl/idlutils.py
+++ b/ovsdbapp/backend/ovs_idl/idlutils.py
@@ -23,7 +23,6 @@ from ovs.db import idl
 from ovs import jsonrpc
 from ovs import poller
 from ovs import stream
-import six
 
 from ovsdbapp import api
 from ovsdbapp import exceptions
@@ -210,7 +209,7 @@ def condition_match(row, condition):
     #                I haven't investigated the reason for the patch that
     #                added this code, but for now I check string_types
     if type(match) is not type(val) and not all(
-            isinstance(x, six.string_types) for x in (match, val)):
+            isinstance(x, str) for x in (match, val)):
         # Types of 'val' and 'match' arguments MUST match in all cases with 2
         # exceptions:
         # - 'match' is an empty list and column's type is optional;
@@ -294,11 +293,11 @@ def db_replace_record(obj):
     api.Command object.
     """
     if isinstance(obj, collections.Mapping):
-        for k, v in six.iteritems(obj):
+        for k, v in obj.items():
             if isinstance(v, api.Command):
                 obj[k] = v.result
     elif (isinstance(obj, collections.Sequence) and
-          not isinstance(obj, six.string_types)):
+          not isinstance(obj, str)):
         for i, v in enumerate(obj):
             if isinstance(v, api.Command):
                 try:
diff --git a/ovsdbapp/backend/ovs_idl/linux/connection_utils.py b/ovsdbapp/backend/ovs_idl/linux/connection_utils.py
index fa8f480f..61616824 100644
--- a/ovsdbapp/backend/ovs_idl/linux/connection_utils.py
+++ b/ovsdbapp/backend/ovs_idl/linux/connection_utils.py
@@ -14,8 +14,6 @@
 
 import os
 
-import six
-
 from ovsdbapp.backend.ovs_idl.common import base_connection_utils
 
 
@@ -31,7 +29,7 @@ class WaitQueue(base_connection_utils.WaitQueue):
         self.alertin.read(1)
 
     def alert_notify(self):
-        self.alertout.write(six.b('X'))
+        self.alertout.write('X'.encode("latin-1"))
         self.alertout.flush()
 
     @property
diff --git a/ovsdbapp/backend/ovs_idl/transaction.py b/ovsdbapp/backend/ovs_idl/transaction.py
index 26308f68..74c12b09 100644
--- a/ovsdbapp/backend/ovs_idl/transaction.py
+++ b/ovsdbapp/backend/ovs_idl/transaction.py
@@ -13,10 +13,10 @@
 #    under the License.
 
 import logging
+import queue
 import time
 
 from ovs.db import idl
-from six.moves import queue as Queue
 
 from ovsdbapp import api
 from ovsdbapp.backend.ovs_idl import idlutils
@@ -32,7 +32,7 @@ class Transaction(api.Transaction):
         self.check_error = check_error
         self.log_errors = log_errors
         self.commands = []
-        self.results = Queue.Queue(1)
+        self.results = queue.Queue(1)
         self.ovsdb_connection = ovsdb_connection
         self.timeout = timeout or ovsdb_connection.timeout
 
@@ -52,7 +52,7 @@ class Transaction(api.Transaction):
         self.ovsdb_connection.queue_txn(self)
         try:
             result = self.results.get(timeout=self.timeout)
-        except Queue.Empty:
+        except queue.Empty:
             raise exceptions.TimeoutException(commands=self.commands,
                                               timeout=self.timeout)
         if isinstance(result, idlutils.ExceptionResult):
diff --git a/ovsdbapp/event.py b/ovsdbapp/event.py
index 285fc896..963e6e1d 100644
--- a/ovsdbapp/event.py
+++ b/ovsdbapp/event.py
@@ -13,17 +13,14 @@
 import abc
 import atexit
 import logging
+import queue
 import threading
 
-import six
-from six.moves import queue as Queue
-
 LOG = logging.getLogger(__name__)
 STOP_EVENT = ("STOP", None, None, None)
 
 
-@six.add_metaclass(abc.ABCMeta)
-class RowEvent(object):
+class RowEvent(object, metaclass=abc.ABCMeta):
     ROW_CREATE = "create"
     ROW_UPDATE = "update"
     ROW_DELETE = "delete"
@@ -98,7 +95,7 @@ class RowEventHandler(object):
     def __init__(self):
         self.__watched_events = set()
         self.__lock = threading.Lock()
-        self.notifications = Queue.Queue()
+        self.notifications = queue.Queue()
         self.notify_thread = threading.Thread(target=self.notify_loop)
         self.notify_thread.daemon = True
         atexit.register(self.shutdown)
diff --git a/ovsdbapp/exceptions.py b/ovsdbapp/exceptions.py
index 94de1ff9..f1f0f8c8 100644
--- a/ovsdbapp/exceptions.py
+++ b/ovsdbapp/exceptions.py
@@ -12,8 +12,6 @@
 #    License for the specific language governing permissions and limitations
 #    under the License.
 
-import six
-
 
 class OvsdbAppException(RuntimeError):
     """Base OvsdbApp Exception.
@@ -34,10 +32,6 @@ class OvsdbAppException(RuntimeError):
             # at least get the core message out if something happened
             super(OvsdbAppException, self).__init__(self.message)
 
-    if six.PY2:
-        def __unicode__(self):
-            return unicode(self.msg)  # noqa pylint: disable=undefined-variable
-
     def __str__(self):
         return self.msg
 
diff --git a/ovsdbapp/schema/open_vswitch/api.py b/ovsdbapp/schema/open_vswitch/api.py
index c12ce701..c9f499d3 100644
--- a/ovsdbapp/schema/open_vswitch/api.py
+++ b/ovsdbapp/schema/open_vswitch/api.py
@@ -14,13 +14,10 @@
 
 import abc
 
-import six
-
 from ovsdbapp import api
 
 
-@six.add_metaclass(abc.ABCMeta)
-class API(api.API):
+class API(api.API, metaclass=abc.ABCMeta):
     @abc.abstractmethod
     def add_manager(self, connection_uri):
         """Create a command to add a Manager to the OVS switch
diff --git a/ovsdbapp/schema/ovn_northbound/api.py b/ovsdbapp/schema/ovn_northbound/api.py
index 6b9c6a34..7e1d44da 100644
--- a/ovsdbapp/schema/ovn_northbound/api.py
+++ b/ovsdbapp/schema/ovn_northbound/api.py
@@ -12,14 +12,11 @@
 
 import abc
 
-import six
-
 from ovsdbapp import api
 from ovsdbapp import constants as const
 
 
-@six.add_metaclass(abc.ABCMeta)
-class API(api.API):
+class API(api.API, metaclass=abc.ABCMeta):
     """An API based off of the ovn-nbctl CLI interface
 
     This API basically mirrors the ovn-nbctl operations with these changes:
diff --git a/ovsdbapp/schema/ovn_southbound/api.py b/ovsdbapp/schema/ovn_southbound/api.py
index cc3106e8..74179f4b 100644
--- a/ovsdbapp/schema/ovn_southbound/api.py
+++ b/ovsdbapp/schema/ovn_southbound/api.py
@@ -12,13 +12,10 @@
 
 import abc
 
-import six
-
 from ovsdbapp import api
 
 
-@six.add_metaclass(abc.ABCMeta)
-class API(api.API):
+class API(api.API, metaclass=abc.ABCMeta):
     """An API based off of the ovn-sbctl CLI interface
 
     This API basically mirrors the ovn-nbctl operations with these changes:
diff --git a/requirements.txt b/requirements.txt
index ff6ceb46..153b5ff0 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -6,4 +6,3 @@ fixtures>=3.0.0 # Apache-2.0/BSD
 netaddr>=0.7.18 # BSD
 ovs>=2.8.0 # Apache-2.0
 pbr!=2.1.0,>=2.0.0 # Apache-2.0
-six>=1.10.0 # MIT
diff --git a/tools/debug_venv.py b/tools/debug_venv.py
index 78d09003..cee9fb06 100755
--- a/tools/debug_venv.py
+++ b/tools/debug_venv.py
@@ -14,7 +14,6 @@
 from __future__ import print_function
 import atexit
 import os
-import six
 import subprocess
 import sys
 
@@ -22,6 +21,19 @@ from fixtures import fixture
 
 from ovsdbapp import venv
 
+
+def reraise(tp, value, tb=None):
+    try:
+        if value is None:
+            value = tp()
+        if value.__traceback__ is not tb:
+            raise value.with_traceback(tb)
+        raise value
+    finally:
+        value = None
+        tb = None
+
+
 if len(sys.argv) != 4:
     print("Requires three arguments: venvdir ovsdir ovndir", file=sys.stderr)
     sys.exit(1)
@@ -40,7 +52,7 @@ try:
     atexit.register(v.cleanUp)
     v.setUp()
 except fixture.MultipleExceptions as e:
-    six.reraise(*e.args[0])
+    reraise(*e.args[0])
 try:
     print("*** Exit the shell when finished debugging ***")
     subprocess.call([os.getenv('SHELL'), '-i'], env=v.env)
diff --git a/tox.ini b/tox.ini
index 5b85469d..0803ce59 100644
--- a/tox.ini
+++ b/tox.ini
@@ -5,6 +5,7 @@ skipsdist = True
 ignore_basepython_conflict = True
 
 [testenv]
+basepython = python3
 usedevelop = True
 setenv =
    VIRTUAL_ENV={envdir}
@@ -18,7 +19,6 @@ deps =
 commands = stestr run --slowest {posargs}
 
 [testenv:pep8]
-basepython= python3
 commands = flake8
            {toxinidir}/tools/coding-checks.sh --all '{posargs}'