diff --git a/global-requirements.txt b/global-requirements.txt
index 99d03b0cc8..db2a819c31 100644
--- a/global-requirements.txt
+++ b/global-requirements.txt
@@ -459,7 +459,8 @@ selenium  # Apache-2.0
 # situations as progressive releases of projects are done.
 # Blacklist setuptools 34.0.0-34.3.2 due to https://github.com/pypa/setuptools/issues/951
 # Blacklist setuptools 36.2.0 due to https://github.com/pypa/setuptools/issues/1086
-setuptools!=24.0.0,!=34.0.0,!=34.0.1,!=34.0.2,!=34.0.3,!=34.1.0,!=34.1.1,!=34.2.0,!=34.3.0,!=34.3.1,!=34.3.2,!=36.2.0  # PSF/ZPL
+setuptools!=24.0.0,!=34.0.0,!=34.0.1,!=34.0.2,!=34.0.3,!=34.1.0,!=34.1.1,!=34.2.0,!=34.3.0,!=34.3.1,!=34.3.2,!=36.2.0;python_version>='3.5'  # PSF/ZPL
+setuptools!=24.0.0,!=34.0.0,!=34.0.1,!=34.0.2,!=34.0.3,!=34.1.0,!=34.1.1,!=34.2.0,!=34.3.0,!=34.3.1,!=34.3.2,!=36.2.0,<45.0.0;python_version<='2.7'  # PSF/ZPL
 sphinx!=1.6.6,!=1.6.7,<2.0.0;python_version=='2.7'  # BSD
 sphinx!=1.6.6,!=1.6.7,!=2.1.0;python_version>='3.4'  # BSD
 sphinx-testing  # BSD License