diff --git a/global-requirements.txt b/global-requirements.txt
index 2cafd144db..1da3d0dfb2 100644
--- a/global-requirements.txt
+++ b/global-requirements.txt
@@ -318,7 +318,6 @@ Routes  # MIT
 rtslib-fb  # Apache-2.0
 rst2txt  # BSD
 ruamel.yaml  # MIT
-ryu  # Apache-2.0
 semantic-version  # BSD
 # https://github.com/harlowja/fasteners/issues/36
 fasteners!=0.15,!=0.16  # Apache-2.0
diff --git a/tox.ini b/tox.ini
index 25daabfcad..78a3410da2 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,11 +1,7 @@
 [tox]
-minversion = 3.2.0
+minversion = 4.11.0
 envlist = validate,py3,pep8,pip-install
 ignore_basepython_conflict=true
-# NOTE(elod.illes): with latest virtualenv (and setuptools bundled in
-# it) py3*-check-uc jobs started to fail as pkg_resources' __getattr__
-# breaks on packages metadata
-requires = virtualenv<20.18
 
 [testenv]
 basepython = python3
diff --git a/upper-constraints.txt b/upper-constraints.txt
index c999329714..1599e80f95 100644
--- a/upper-constraints.txt
+++ b/upper-constraints.txt
@@ -18,7 +18,6 @@ XStatic-Angular-Bootstrap===2.5.0.0
 WebOb===1.8.7
 sphinxcontrib-actdiag===3.0.0
 pecan===1.4.2
-ryu===4.34
 os-api-ref===2.3.0
 python-ldap===3.4.3
 oslo.concurrency===5.2.0