diff --git a/.zuul.yaml b/.zuul.yaml
index e1c63c8b0..b36638c68 100644
--- a/.zuul.yaml
+++ b/.zuul.yaml
@@ -9,6 +9,7 @@
       - zuul/nodepool
     vars:
       minikube_version: v1.25.2  # NOTE(corvus): https://github.com/kubernetes/minikube/issues/14403 https://github.com/kubernetes/minikube/issues/14397
+    nodeset: ubuntu-jammy
 
 - job:
     description: |
@@ -51,8 +52,8 @@
     dependencies:
       - opendev-buildset-registry
     requires:
-      - python-builder-3.9-bullseye-container-image
-      - python-base-3.9-bullseye-container-image
+      - python-builder-3.10-bullseye-container-image
+      - python-base-3.10-bullseye-container-image
     provides: nodepool-container-image
     vars: &nodepool_image_vars
       docker_images:
@@ -87,8 +88,8 @@
     description: Build Docker images and upload to Docker Hub.
     timeout: *image_build_timeout
     requires:
-      - python-builder-3.9-bullseye-container-image
-      - python-base-3.9-bullseye-container-image
+      - python-builder-3.10-bullseye-container-image
+      - python-base-3.10-bullseye-container-image
     provides: nodepool-container-image
     vars: *nodepool_image_vars
     secrets:
@@ -117,8 +118,8 @@
       - zuul/nodepool
       - openstack/diskimage-builder
     requires:
-      - python-builder-3.9-bullseye-container-image
-      - python-base-3.9-bullseye-container-image
+      - python-builder-3.10-bullseye-container-image
+      - python-base-3.10-bullseye-container-image
     provides: nodepool-siblings-container-image
     vars:
       zuul_work_dir: "{{ zuul.projects['opendev.org/zuul/nodepool'].src_dir }}"
@@ -164,6 +165,7 @@
     vars:
       zuul_copy_output:
         /var/log/nodepool: logs
+    nodeset: ubuntu-jammy
 
 - job:
     name: nodepool-functional-container-openstack-release-base
@@ -243,12 +245,13 @@
         NODEPOOL_ZK_KEY: /opt/zookeeper/ca/keys/clientkey.pem
 
 - job:
-    name: nodepool-tox-py39
+    name: nodepool-tox-py310
     description: |
       Nodepool unit tests with ZooKeeper running
-    parent: tox-py39
+    parent: tox-py310
     pre-run: playbooks/nodepool-tox/pre.yaml
     vars: *nodepool_tox_vars
+    nodeset: ubuntu-jammy
 
 - project:
     vars:
@@ -258,9 +261,10 @@
         - opendev-buildset-registry
         - nodepool-build-image
         - zuul-tox-docs
-        - tox-pep8
+        - tox-pep8:
+            nodeset: ubuntu-jammy
         - nodepool-tox-py38
-        - nodepool-tox-py39
+        - nodepool-tox-py310
         - nodepool-functional-container-openstack-release
         - nodepool-functional-k8s
         - nodepool-functional-openshift
@@ -272,9 +276,10 @@
       jobs:
         - nodepool-upload-image
         - zuul-tox-docs
-        - tox-pep8
+        - tox-pep8:
+            nodeset: ubuntu-jammy
         - nodepool-tox-py38
-        - nodepool-tox-py39
+        - nodepool-tox-py310
         - nodepool-functional-k8s
         - nodepool-functional-openshift
         - zuul-quick-start:
diff --git a/Dockerfile b/Dockerfile
index 5d25a909a..73fa3632d 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -13,19 +13,14 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-FROM docker.io/opendevorg/python-builder:3.9-bullseye as builder
+FROM docker.io/opendevorg/python-builder:3.10-bullseye as builder
 # ============================================================================
 
 ARG ZUUL_SIBLINGS=""
 COPY . /tmp/src
-RUN if [ `uname -m` = "aarch64" ] ; then \
-      echo "Installing arm64 pip.conf" ; \
-      cp /tmp/src/tools/pip.conf.arm64 /etc/pip.conf ; \
-      cp /tmp/src/tools/pip.conf.arm64 /output/pip.conf ; \
-    fi
 RUN assemble
 
-FROM docker.io/opendevorg/python-base:3.9-bullseye as nodepool-base
+FROM docker.io/opendevorg/python-base:3.10-bullseye as nodepool-base
 # ============================================================================
 
 COPY --from=builder /output/ /output
diff --git a/bindep.txt b/bindep.txt
index 12142228f..e7e2a01c2 100644
--- a/bindep.txt
+++ b/bindep.txt
@@ -5,8 +5,9 @@ gcc [compile test]
 libc6-dev [compile test platform:dpkg]
 libffi-dev [compile test platform:dpkg platform:apk]
 libffi [platform:apk]
+libffi8 [platform:ubuntu-jammy]
 libffi7 [platform:ubuntu-focal platform:debian-bullseye]
-libffi6 [platform:dpkg !platform:ubuntu-focal !platform:debian-bullseye]
+libffi6 [platform:dpkg !platform:ubuntu-focal !platform:ubuntu-jammy !platform:debian-bullseye]
 libffi-devel [compile test platform:rpm]
 libressl-dev [compile test platform:apk]
 libssl-dev [compile test platform:dpkg]
diff --git a/setup.cfg b/setup.cfg
index 6d2ad8488..c5df195eb 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -16,6 +16,7 @@ classifier =
     Programming Language :: Python :: 3
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
 
 [pbr]
 warnerrors = True
diff --git a/tools/pip.conf.arm64 b/tools/pip.conf.arm64
deleted file mode 100644
index c2f8825c5..000000000
--- a/tools/pip.conf.arm64
+++ /dev/null
@@ -1,5 +0,0 @@
-[global]
-extra-index-url = https://mirror.dfw.rax.opendev.org/wheel/debian-11-aarch64/
-
-[install]
-prefer-binary = true