diff --git a/doc/source/python-jobs.rst b/doc/source/python-jobs.rst
index 82dd3faa2..9437e7f3d 100644
--- a/doc/source/python-jobs.rst
+++ b/doc/source/python-jobs.rst
@@ -8,6 +8,7 @@ Python Jobs
 .. zuul:autojob:: tox-py37
 .. zuul:autojob:: tox-py38
 .. zuul:autojob:: tox-py39
+.. zuul:autojob:: tox-py310
 .. zuul:autojob:: tox-docs
 .. zuul:autojob:: tox-linters
 .. zuul:autojob:: tox-molecule
diff --git a/zuul-tests.d/project.yaml b/zuul-tests.d/project.yaml
index eedd69178..c9192d1a7 100644
--- a/zuul-tests.d/project.yaml
+++ b/zuul-tests.d/project.yaml
@@ -10,6 +10,11 @@
         - tox-py38
         - tox-py39:
             nodeset: ubuntu-focal
+        - tox-py310:
+            nodeset:
+              nodes:
+                - name: fedora-35
+                  label: fedora-35
     gate:
       jobs:
         - zuul-tox-docs
@@ -17,6 +22,11 @@
         - tox-py38
         - tox-py39:
             nodeset: ubuntu-focal
+        - tox-py310:
+            nodeset:
+              nodes:
+                - name: fedora-35
+                  label: fedora-35
     promote:
       jobs:
         - zuul-promote-docs
diff --git a/zuul.d/python-jobs.yaml b/zuul.d/python-jobs.yaml
index cc9a8e897..5fe00ab2a 100644
--- a/zuul.d/python-jobs.yaml
+++ b/zuul.d/python-jobs.yaml
@@ -181,6 +181,17 @@
       tox_envlist: py39
       python_version: 3.9
 
+- job:
+    name: tox-py310
+    parent: tox
+    description: |
+      Run unit tests for a Python project under cPython version 3.10.
+
+      Uses tox with the ``py310`` environment.
+    vars:
+      tox_envlist: py310
+      python_version: "3.10"
+
 - job:
     name: tox-docs
     # This is not parented to tox since we do not need